Article
Identification of B6SJL mSOD1(G93A) mouse subgroups with different disease progression rates.
The Journal of comparative neurology - 15 Dec 2015
Haulcomb Melissa M, Mesnard-Hoaglin Nichole A, Batka Richard J, Meadows Rena M, Miller Whitney M, Mcmillan Kathryn P, Brown Todd J, Sanders Virginia M, Jones Kathryn J
Abstract excerpt
Disease progression rates among patients with amyotrophic lateral sclerosis (ALS) vary greatly. Although the majority of affected individuals survive 3-5 years following diagnosis, some subgroups experience a more rapidly progressing form, surviving less than 1 year, and other subgroups experience slowly progressing forms, surviving nearly 50 years. Genetic heterogeneity and environmental factors pose significant...
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