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Article

Comparative study of behavioural tests in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Experimental animals - 1 Jan 2015

Oliván Sara, Calvo Ana Cristina, Rando Amaya, Muñoz María Jesús, Zaragoza Pilar, Osta Rosario

Abstract excerpt

In preclinical trials, a sensitive functional test is required to detect changes in the motor behaviour of the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS). We evaluated changes in body weight and motor impairment in behavioural tests, such as the rotarod, the hanging-wire test and the treadmill, of transgenic and wild type mice. We found differences in detection of the onset of symptoms and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25736480
DOI: 10.1538/expanim.14-0077
PMCID: PMC4427729

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