Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

10 Mar 2010

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs) that causes skeletal muscle paralysis. Familial forms of ALS are linked to mutations in the superoxide dismutase-1 (SOD1) gene. The mechanisms of human SOD1 (hSOD1) toxicity to MNs are unknown. We hypothesized that skeletal muscle is a primary site of pathogenesis in ALS that triggers MN degeneration. We created...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20223753
DOI: 10.1093/hmg/ddq106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic micePMID 20223753Read ↗

Skeletal Muscle-Restricted Expression of Human SOD1 in Transgenic Mice Causes a Fatal ALS-Like SyndromeSemantic proximity Read ↗

Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology.Semantic proximity Read ↗

A Drosophila Model for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1Semantic proximity Read ↗

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1.Semantic proximity Read ↗

Pathological Sequelae Associated with Skeletal Muscle Atrophy and Histopathology in G93A*SOD1 MiceSemantic proximity Read ↗

Mechanism and treatment of motoneuron degeneration in ALS: what have SOD1 mutants told us?Semantic proximity Read ↗

Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities.Semantic proximity Read ↗

Aberrant DNA and RNA Methylation Occur in Spinal Cord and Skeletal Muscle of Human SOD1 Mouse Models of ALS and in Human ALS: Targeting DNA Methylation Is TherapeuticSemantic proximity Read ↗

Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.Semantic proximity Read ↗

Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.Semantic proximity Read ↗

Skeletal Muscle Satellite Cells, Mitochondria, and MicroRNAs: Their Involvement in the Pathogenesis of ALSSemantic proximity Read ↗

ALS: a disease of motor neurons and their nonneuronal neighbors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.