Article
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.
Genome research - 1 Mar 2015
Kim Hoon, Zheng Siyuan, Amini Seyed S, Virk Selene M, Mikkelsen Tom, Brat Daniel J, Grimsby Jonna, Sougnez Carrie, Muller Florian, Hu Jian, Sloan Andrew E, Cohen Mark L, Van Meir Erwin G, Scarpace Lisa, Laird Peter W, Weinstein John N, Lander Eric S, Gabriel Stacey, Getz Gad, Meyerson Matthew, Chin Lynda, Barnholtz-Sloan Jill S, Verhaak Roel G W
Abstract excerpt
Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence ∼ 7 mo after diagnosis. Understanding the molecular architecture of this residual population is critical for the development of successful therapies. We used whole-genome sequencing and...
Topics
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Brain Neoplasms
- Clonal Evolution
- DNA Copy Number Variations
- DNA Methylation
- Exome