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Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression

1 Jan 2020

Abstract excerpt

BACKGROUND: Tumor heterogeneity underlies resistance and disease progression in glioblastoma (GBM), and tumors most commonly recur adjacent to the surgical resection margins in contrast non-enhancing (NE) regions. To date, no targeted therapies have meaningfully altered overall patient survival in the up-front setting. The aim of this study was to characterize intratumoral heterogeneity in recurrent GBM using...

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PMID: 32743548
DOI: 10.1093/noajnl/vdaa078

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