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Article

Clonal evolution of glioblastoma under therapy.

Nature genetics - 1 Jul 2016

Wang Jiguang, Cazzato Emanuela, Ladewig Erik, Frattini Veronique, Rosenbloom Daniel I S, Zairis Sakellarios, Abate Francesco, Liu Zhaoqi, Elliott Oliver, Shin Yong-Jae, Lee Jin-Ku, Lee In-Hee, Park Woong-Yang, Eoli Marica, Blumberg Andrew J, Lasorella Anna, Nam Do-Hyun, Finocchiaro Gaetano, Iavarone Antonio, Rabadan Raul

Abstract excerpt

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data from 114 patients. The analysis shows a highly branched evolutionary pattern in which 63% of patients experience expression-based subtype changes. The branching pattern, together with estimates of evolutionary rate, suggests that...

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Identifiers

PMID: 27270107
DOI: 10.1038/ng.3590
PMCID: PMC5627776

Genes

LTBP4
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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