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Article

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

6 Jan 2023

Abstract excerpt

PURPOSE: Glioblastoma(GBM) is a lethal disease characterized by inevitable recurrence. Here we investigate the molecular pathways mediating resistance, with the goal of identifying novel therapeutic opportunities. EXPERIMENTAL DESIGN: We developed a longitudinal in vivo recurrence model utilizing patient-derived explants to produce paired specimens(pre- and post-recurrence) following temozolomide(TMZ) and...

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PMID: 36621024
DOI: 10.1016/j.neo.2022.100872

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