Article
An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis
30 Oct 2021
Abstract excerpt
BACKGROUND: Pancreatic β-cells are the insulin factory of an organism with a mission to regulate glucose homeostasis in the body. Due to their high secretory activity, β-cells rely on a functional and intact endoplasmic reticulum (ER). Perturbations to ER homeostasis and unmitigated stress lead to β-cell dysfunction and death. Type 1 diabetes (T1D) is a chronic inflammatory disease caused by the...
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