Article
Improvement of ER stress-induced diabetes by stimulating autophagy.
Autophagy - 1 Apr 2013
Bachar-Wikstrom Etty, Wikstrom Jakob D, Kaiser Nurit, Cerasi Erol, Leibowitz Gil
Abstract excerpt
Pancreatic β-cell dysfunction is central in diabetes. The diabetic milieu may impair proinsulin folding, leading to β-cell endoplasmic reticulum (ER) stress and apoptosis, and thus a worsening of the diabetes. Autophagy is crucial for the well-being of the β-cell; however, the impact of stimulating autophagy on β-cell adaptation to ER stress is unknown. We studied the crosstalk between ER stress and autophagy in...
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