Article
p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014
Winnay Jonathon N, Dirice Ercument, Liew Chong Wee, Kulkarni Rohit N, Kahn C Ronald
Abstract excerpt
In insulin resistant states such as type 2 diabetes, there is a high demand on the β-cell to synthesize and secrete insulin, which challenges the ability of the endoplasmic reticulum (ER) to synthesize and fold nascent proteins. This creates a state of ER stress that triggers a coordinated program referred to as the unfolded protein response (UPR) that attempts to restore ER homeostasis. We identified a role for...
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