Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence.

Frontiers in endocrinology - 1 Jan 2021

Shrestha Neha, De Franco Elisa, Arvan Peter, Cnop Miriam

Abstract excerpt

The notion that in diabetes pancreatic β-cells express endoplasmic reticulum (ER) stress markers indicative of increased unfolded protein response (UPR) signaling is no longer in doubt. However, what remains controversial is whether this increase in ER stress response actually contributes importantly to the β-cell failure of type 2 diabetes (akin to 'terminal UPR'), or whether it represents a coping mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Endoplasmic Reticulum Stress
Share to Endoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Insulin-Secreting Cells

Share to Protein Denaturation

Share to Protein Folding

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 33967960
DOI: 10.3389/fendo.2021.650158
PMCID: PMC8101261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence.PMID 33967960Read ↗

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.Semantic proximity Read ↗

An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesisSemantic proximity Read ↗

Role of the Unfolded Protein Response in<i>β</i>Cell Compensation and Failure during DiabetesSemantic proximity Read ↗

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitusSemantic proximity Read ↗

Inside the β Cell: Molecular Stress Response Pathways in Diabetes PathogenesisSemantic proximity Read ↗

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetesSemantic proximity Read ↗

A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?Semantic proximity Read ↗

A switch from life to death in endoplasmic reticulum stressed <i>β</i> ‐cellsSemantic proximity Read ↗

The Role of Endoplasmic Reticulum Stress in Human PathologySemantic proximity Read ↗

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Semantic proximity Read ↗

The binary switch between life and death of endoplasmic reticulum-stressed β cellsSemantic proximity Read ↗

β- cell dynamics in type 2 diabetes and in dietary and exercise interventionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.