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A non-coding variant at 2p24.2 confers susceptibility to non-syndromic cleft lip and palate through LLPS-dependent regulation of <i>MYCN</i>

2026-04-07

Abstract excerpt

Non-syndromic cleft lip and palate (NSCLP) represents the most prevalent and clinically severe subtype within non-syndromic orofacial cleft (NSOFC), and 2p24.2 is the most significant reported risk locus for NSCLP. However, the causal variant at 2p24.2 and the underlying pathogenic mechanism remain unclear, limiting clinical translation. Here, we defined a 104-kb linkage disequilibrium (LD) block tagged by the lea...

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Literature Corpus work
8c464d5b-68fe-54a5-bb2e-5faf8fae0e67
DOI
10.64898/2026.04.07.26350283
Open publication

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A non-coding variant at 2p24.2 confers susceptibility to non-syndromic cleft lip and palate through LLPS-dependent regulation of <i>MYCN</i>DOI 10.64898/2026.04.07.26350283
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