Article

Flexible regions in the molecular architecture of Human fibrin clots structurally resolved by XL-MS and integrative structural modeling

2019-08-19

Abstract excerpt

Upon activation, fibrinogen forms large fibrin biopolymers that coalesce into clots that assist in wound healing. Limited insights into their molecular architecture, due to the sheer size and insoluble character of fibrin clots, have however restricted our ability to develop novel treatments for clotting diseases. The so far resolved disparate structural details did provide insights into linear elongation; however...

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Literature Corpus work: 8c2f6957-baf5-5f51-9fc8-f1e23e52e7d5
DOI: 10.1101/739318

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