Fibrinogen Hillsborough: a novel gammaGly309Asp dysfibrinogen with impaired clotting.

doi:10.1182/blood.v99.10.3597

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Article

Fibrinogen Hillsborough: a novel gammaGly309Asp dysfibrinogen with impaired clotting.

Blood - 15 May 2002

Mullin Jennifer L, Brennan Stephen O, Ganly Peter S, George Peter M

Abstract excerpt

We present a novel gamma-chain dysfibrinogen that was discovered in a 32-year-old asymptomatic man admitted to the hospital after a car accident. He presented with a low fibrinogen concentration, 0.5 mg/mL, and a prolonged thrombin clotting time, 58 seconds. Analysis of purified fibrinogen by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a gamma-chain variant with an apparently higher...

Topics

Adult
Amino Acid Sequence
Amino Acid Substitution
Animals
Aspartic Acid
Biopolymers
Blood Coagulation
Fibrinogens, Abnormal
Glycine
Humans
Male
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Molecular Weight

Mutation

Protein Subunits

Sequence Homology, Amino Acid

Thrombin

Source

Open in PubMed

Identifiers

PMID: 11986213
DOI: 10.1182/blood.v99.10.3597

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