Article

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

2022-09-05

Abstract excerpt

Fibrinogen is a soluble, multi-subunit and multi-domain dimeric protein, which, upon its proteolytic cleavage by thrombin, is converted to insoluble fibrin initiating polymerization that substantially contributes to clot growth. The consentaneous structural view of the soluble form of fibrinogen is relatively straight and rigid-like. However, fibrinogen contains numerous, transiently-accessible “cryptic” epitopes...

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Literature Corpus work: c2ce5994-c259-5a8e-9fcf-af6a693ce4eb
DOI: 10.1101/2022.09.05.506423

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