Article
A three-dimensional consideration of variant human fibrinogens.
Thrombosis and haemostasis - 1 Jul 1998
Everse S J, Spraggon G, Doolittle R F
Abstract excerpt
Recently reported X-ray structures for large core fragments derived from human fibrinogen and fibrin make it possible to correlate structural and functional anomalies of known genetic variants. Here we examine a variety of amino acid replacements previously reported for hereditary dysfibrinogenem...
Topics
- Amino Acid Substitution
- Fibrin Fibrinogen Degradation Products
- Fibrinogen
- Fibrinogens, Abnormal
- Genetic Variation
- Humans
- Models, Molecular
- Molecular Weight
- Mutation
- X-Ray Diffraction