Three-dimensional structural studies on fragments of fibrinogen and fibrin.

doi:10.1016/s0959-440x(98)80100-0

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Article

Three-dimensional structural studies on fragments of fibrinogen and fibrin.

Current opinion in structural biology - 1 Dec 1998

Doolittle R F, Spraggon G, Everse S J

Abstract excerpt

Fibrinogen is a 340 kDa glycoprotein found in the blood plasma of all vertebrates. It is transformed into a fibrin clot by the action of thrombin. Recent X-ray structures of core fragments of both fibrinogen and fibrin have revealed many details about this polymerization event. These include stru...

Topics

Calcium
Evolution, Molecular
Fibrin
Fibrinogen
Humans
Mutation
Protein Conformation

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