Article

Proteomic Characterisation of Anomalous Intravascular Casts Reveals Non-Canonical Fibrin Architecture and Impaired Fibrinolysis

2026-01-31

Abstract excerpt

Since early 2021, anomalous intravascular casts (AICs) have been reported that differ markedly from conventional thrombi in morphology, persistence, and mechanical behavior. Prior histological and elemental analyses suggested an atypical clot matrix.We performed blinded proteomic profiling of AIC specimens using HPLC-MS/MS (High Precision Liquid Chromatography - tandem Mass Spectrometry) to characterize their prot...

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Literature Corpus work: 2f67ec83-c22c-5847-9f00-d038b9970b63
DOI: 10.20944/preprints202601.2319.v1

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Proteomic Characterisation of Anomalous Intravascular Casts Reveals Non-Canonical Fibrin Architecture and Impaired FibrinolysisDOI 10.20944/preprints202601.2319.v1Read

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