Article

Proteomic evidence for amyloidogenic cross-seeding in fibrinaloid microclots

2024-07-17

Abstract excerpt

In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein monomers, with protofibrils and fibrils exhibiting a cross-β motif of parallel or antiparallel β-sheets oriented perpendicular to the fibre direction. These protofibrils and fibrils can intertwine to form mature amyloid fibres. Similar phenomena occur in blood from individuals with circulating inflammatory molecules (also...

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Literature Corpus work: 01c680cb-958d-5204-b01c-da8414a6c964
DOI: 10.1101/2024.07.16.603837

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