Article

Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1

2023-10-08

Abstract excerpt

Antibodies have proven highly valuable for therapeutic development; however, they are typically poor candidates for applications that require activation of G protein-coupled receptors (GPCRs), the largest collection of targets for clinically approved drugs. Nanobodies (Nbs), the smallest antibody fragments retaining full antigen-binding capacity, have emerged as promising tools for pharmacologic applications, incl...

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Literature Corpus work: 8c12dd4e-dcd2-5f76-8821-5ba5dd5f5eeb
DOI: 10.1101/2023.10.08.561411

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Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1DOI 10.1101/2023.10.08.561411Read

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