Vascular defects of <i>DYRK1A</i> knockouts are ameliorated by modulating calcium signaling in zebrafish

Abstract excerpt

<h4>ABSTRACT</h4> DYRK1A is a major causative gene in Down syndrome (DS). Reduced incidence of solid tumors and vascular anomalies in DS patients suggests a role of DYRK1A in angiogenesis, but in vivo evidence is lacking. Here, we used zebrafish dyrk1aa mutant embryos to understand DYRK1A function in the cerebral vasculature formation. Zebrafish dyrk1aa mutants exhibited cerebral hemorrhage and defects in an...

Topics

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• Blood Vessels
• Down syndrome and intellectual disability research
• Embryo, Nonmammalian
• Endothelial Cells
• Mutagenesis
• Neovascularization, Physiologic
• Transgenes
• Zebrafish

Identifiers and source

Literature Corpus work

8bfcf383-32dd-59d3-be25-a29a25ac041b

DOI

10.1101/349985