Ccm1 regulates microvascular morphogenesis during angiogenesis.

doi:10.1159/000316851

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Article

Ccm1 regulates microvascular morphogenesis during angiogenesis.

Journal of vascular research - 1 Jan 2011

Liu Huiling, Rigamonti Daniele, Badr Ahmed, Zhang Jun

Abstract excerpt

Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that have a propensity to bleed. The development of some CCMs in humans has been attributed to mutations in CCM1 and CCM2 genes. In animal models, major cardiovascular defects caused by both g...

Topics

Animals
Cell Line
Disease Models, Animal
Embryo, Nonmammalian
Endothelial Cells
Gene Expression Regulation, Developmental
Hemangioma, Cavernous, Central Nervous System
Humans
Microtubule-Associated Proteins
Microvessels
Morphogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Proteins

Mutation

Neovascularization, Physiologic

Zebrafish

Zebrafish Proteins

rac1 GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20926893
DOI: 10.1159/000316851
PMCID: PMC3219476

Genes

CCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-20926893-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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