Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques.

doi:10.1016/j.euroneuro.2026.112780

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Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 May 2026

Pruin Emma, Bartels Meike, Benavente Ernest Diez, van den Dungen Noortje A M, Hoekstra Joost K R, de Kleijn Dominique D P, Landsmeer Lennart P L, Mokry Michal, Pasterkamp Gerard, Penninx Brenda W J H, Peyrot Wouter J, den Ruijter Hester M, van der Laan Sander W, Milaneschi Yuri

Abstract excerpt

The increased risk of atherosclerotic diseases (stroke, coronary artery disease [CAD]) observed in depression may stem from shared pathophysiology. We examined whether: 1) major depression (MD) and atherosclerotic traits share genetic risk, and 2) altered gene expression in various tissues linked to shared genetics has a potential causal role in depression etiology. Data from the largest genome-wide association...

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PMID: 41616639
DOI: 10.1016/j.euroneuro.2026.112780

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