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Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques

2025-07-11

Abstract excerpt

<h4>Background</h4> The increased risk of atherosclerotic diseases (stroke, coronary artery disease [CAD]) observed in depression may stem from shared pathophysiology. We examined whether: 1) major depression (MD) and atherosclerotic traits share genetic risk, and 2) altered gene expression in various tissues linked to shared genetics has a potential causal role in depression etiology. <h4>Methods</h4> Data from...

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Literature Corpus work
88a029ff-a572-5d76-95e7-34583fc3eb95
DOI
10.1101/2025.07.11.25331336
Open publication

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Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaquesDOI 10.1101/2025.07.11.25331336
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