Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.

doi:10.1038/s41380-019-0614-y

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Article

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.

Molecular psychiatry - 1 Aug 2021

Dennis Jessica, Sealock Julia, Levinson Rebecca T, Farber-Eger Eric, Franco Jacob, Fong Sarah, Straub Peter, Hucks Donald, Song Wen-Liang, Linton MacRae F, Fontanillas Pierre, Elson Sarah L, Ruderfer Douglas, Abdellaoui Abdel, Sanchez-Roige Sandra, Palmer Abraham A, Boomsma Dorret I, Cox Nancy J, Chen Guanhua, Mosley Jonathan D, Wells Quinn S, Davis Lea K

Abstract excerpt

Major depressive disorder (MDD) and loneliness are phenotypically and genetically correlated with coronary artery disease (CAD), but whether these associations are explained by pleiotropic genetic variants or shared comorbidities is unclear. To tease apart these scenarios, we first assessed the medical morbidity pattern associated with genetic risk factors for MDD and loneliness by conducting a phenome-wide...

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PMID: 31796895
DOI: 10.1038/s41380-019-0614-y
PMCID: PMC7266730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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