Article

Streamlined isolation of the n-terminome via phosphonate tagging and coordination-based depletion

2025-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Protein degradation is critical for regulating cellular functions. Therefore, there is considerable interest in developing effective proteome-wide strategies to identify protease cleavage products to enhance our understanding of proteolytic pathways and their perturbation in diseases. Here, we present a streamlined N-termini proteome analysis leveraging N-Hydroxysuccinimide (NHS) ester chemistry...

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Literature Corpus work: aafe63b1-2d60-5784-bea3-b5489c1fcafc
DOI: 10.1101/2025.05.30.657046

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