Article

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19

2020-11-23

Abstract excerpt

<h4>ABSTRACT</h4> Two proteases produced by the SARS-CoV-2 virus, M pro and PL pro , are essential for viral replication and have become the focus of drug development programs for treatment of COVID-19. We screened a highly focused library of compounds containing covalent warheads designed to target cysteine proteases to identify new lead scaffolds for both M pro and PL pro proteases. These efforts identified...

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Literature Corpus work: 5ff8c6d1-007b-5c55-9ce3-86cba6e43935
DOI: 10.1101/2020.11.21.392753

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