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Article

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

Nature communications - 21 Sept 2021

Meyer Bjoern, Chiaravalli Jeanne, Gellenoncourt Stacy, Brownridge Philip, Bryne Dominic P, Daly Leonard A, Grauslys Arturas, Walter Marius, Agou Fabrice, Chakrabarti Lisa A, Craik Charles S, Eyers Claire E, Eyers Patrick A, Gambin Yann, Jones Andrew R, Sierecki Emma, Verdin Eric, Vignuzzi Marco, Emmott Edward

Abstract excerpt

SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over 170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and vaccinate against this pathogen all benefit from an improved understanding of the basic biology of SARS-CoV-2. Both viral and cellular proteases play a crucial role in SARS-CoV-2 replication. Here, we study proteolytic cleavage of viral and...

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Source

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Identifiers

PMID: 34548480
DOI: 10.1038/s41467-021-25796-w
PMCID: PMC8455558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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