Article

Atrophy in multiple system atrophy relates to mitochondrial and oligodendrocytic processes

2025-01-23

Abstract excerpt

<h4>Objective</h4> To investigate the gene expression and neurobiological underpinnings of brain atrophy in multiple system atrophy (MSA) using imaging transcriptomics and PET-based molecular annotation. <h4>Methods</h4> We derived brain atrophy measurements from the T1-weighted MRI scans of 65 patients with MSA and 181 age- and sex-matched healthy controls. Using postmortem data from the Allen Human Brain Atlas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bd9df79-9670-5de9-b31c-73026d83f009
DOI: 10.1101/2025.01.22.25320961

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atrophy in multiple system atrophy relates to mitochondrial and oligodendrocytic processesDOI 10.1101/2025.01.22.25320961Read

MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patternsSemantic proximity Read

Transcriptional profiling of Multiple System Atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the diseaseSemantic proximity Read

Transcriptomic signatures associated with regional cortical thickness changes in Parkinson’s diseaseSemantic proximity Read

Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal MechanismsSemantic proximity Read

Multiparametric MRI and imaging transcriptomics reveal molecular and cellular correlates of neurodegeneration in experimental parkinsonismSemantic proximity Read

Distinct spatial transcriptomic patterns of substantia nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophySemantic proximity Read

Transcriptomic Analysis and Multiple Machine Learning Approaches Identify ZDHHC20 and Its Highly Correlated Gene AK5 as Diagnostic Markers in Multiple System AtrophySemantic proximity Read

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson’s Disease and Multiple System AtrophySemantic proximity Read

Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's diseaseSemantic proximity Read

Motor Functional Hierarchical Organization of Cerebrum and Its Underlying Genetic Architecture in Parkinson’s DiseaseSemantic proximity Read

Selective Molecular and Network Architecture Features Underlie Brain Cortical Atrophy in Dementia with Lewy BodiesSemantic proximity Read

Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectivesSemantic proximity Read