Article

MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patterns

2025-07-18

Abstract excerpt

<title>Abstract</title> <p>Oligodendroglial pathology is a hallmark of multiple system atrophy (MSA), yet it remains unclear whether MRI-detected atrophy reflects underlying biological mechanisms. This study investigated whether regional atrophy aligns with gene expression and neurotransmitter systems. We recruited 65 MSA patients and derived brain atrophy measures from T1-weighted MRIs.Using postmortem data from...

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Literature Corpus work: 4fe4ca58-f0e2-525b-8878-f16a88e79820
DOI: 10.21203/rs.3.rs-7095251/v1

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