Cas9-induced on-target genomic damage

Abstract excerpt

CRISPR/Cas9 is the gene editing tool of choice in basic research and poised to become one in clinical context. However, current studies on the topic suffer from a number of shortcomings. Mutagenesis is often assessed using bulk methods, which means rare events go undetected, unresolved or are discarded as potential sequencing errors. Many of the genotyping methods rely on short-range PCR, which excludes larger str...

Topics

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• CRISPR-Cas Systems
• Endonucleases
• Gene Targeting
• Genetic Engineering
• CRISPR-Associated Protein 9
• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR and Genetic Engineering
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

8bd4e5dc-a62b-56fd-b98d-ca2f6fb80220

DOI

10.17863/cam.37162