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Article

CRISPR/Cas9 as a Mutagenic Factor.

International journal of molecular sciences - 9 Jan 2024

Shumega Andrey R, Pavlov Youri I, Chirinskaite Angelina V, Rubel Aleksandr A, Inge-Vechtomov Sergey G, Stepchenkova Elena I

Abstract excerpt

The discovery of the CRISPR/Cas9 microbial adaptive immune system has revolutionized the field of genetics, by greatly enhancing the capacity for genome editing. CRISPR/Cas9-based editing starts with DNA breaks (or other lesions) predominantly at target sites and, unfortunately, at off-target genome sites. DNA repair systems differing in accuracy participate in establishing desired genetic changes but also...

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Identifiers

PMID: 38255897
DOI: 10.3390/ijms25020823
PMCID: PMC10815272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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