Article

<i>In vivo</i> CRISPR-Cas gene editing with no detectable genome-wide off-target mutations

2018-02-27

Abstract excerpt

CRISPR-Cas genome-editing nucleases hold substantial promise for human therapeutics 1–5 but identifying unwanted off-target mutations remains an important requirement for clinical translation 6, 7 . For ex vivo therapeutic applications, previously published cell-based genome-wide methods provide potentially useful strategies to identify and quantify these off-target mutation sites 8–12 . However, a well-valida...

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Literature Corpus work: 12974b0a-42dc-5b86-b984-8d80b6937590
DOI: 10.1101/272724

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