Article

Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation

2024-09-19

Abstract excerpt

<h4>Background</h4> Idiopathic Pulmonary fibrosis (IPF) is characterized by progressive scarring and fibrosis within the lungs. There is currently no cure for IPF; therefore, there is an urgent need to identify novel therapeutic targets that can prevent the progression of IPF. Compelling evidence indicates that the second messenger, cyclic adenosine monophosphate (cAMP), inhibits lung fibroblast proliferation and...

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Literature Corpus work: 8a6ff1c5-6c1e-5177-9aad-786de10db81c
DOI: 10.1101/2024.09.13.612935

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