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Article

Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions.

JCI insight - 22 Mar 2021

Fortier Sean M, Penke Loka R, King Dana, Pham Tho X, Ligresti Giovanni, Peters-Golden Marc

Abstract excerpt

Myofibroblasts are the major cellular source of collagen, and their accumulation - via differentiation from fibroblasts and resistance to apoptosis - is a hallmark of tissue fibrosis. Clearance of myofibroblasts by dedifferentiation and restoration of apoptosis sensitivity has the potential to reverse fibrosis. Prostaglandin E2 (PGE2) and mitogens such as FGF2 have each been shown to dedifferentiate...

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Identifiers

PMID: 33561015
DOI: 10.1172/jci.insight.144799
PMCID: PMC8026183

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