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Article

cGAS Expression is Enhanced in Systemic Sclerosis Associated Interstitial Lung Disease and Stimulates Inflammatory Myofibroblast Activation

2024-08-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> The lungs of patients with Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD) contain inflammatory myofibroblasts arising in association with fibrotic stimuli and perturbed innate immunity. The innate immune DNA binding receptor Cyclic GMP-AMP synthase (cGAS) is implicated in inflammation and fibrosis, but its involvement in SSc-ILD remains unknown. We examined...

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Literature Corpus work
a816ed5b-0d3b-5e32-bcb0-c97d470a8593
DOI
10.1101/2024.08.07.24311631
Open publication

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cGAS Expression is Enhanced in Systemic Sclerosis Associated Interstitial Lung Disease and Stimulates Inflammatory Myofibroblast ActivationDOI 10.1101/2024.08.07.24311631
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