Article

NINJ1 mediates necrosis of <i>Mycobacterium tuberculosis</i> infected human macrophages

2025-11-04

Abstract excerpt

Lytic cell death contributes to tissue damage and dissemination during Mycobacterium tuberculosis (Mtb) infection, yet the mechanisms governing plasma membrane rupture (PMR) remain incompletely defined. Here, we identify Ninjurin-1 (NINJ1), a mediator of PMR, as a central effector of macrophage lysis during Mtb infection. Mtb infection induced NINJ1 oligomerization, and genetic deletion or pharmacological inhibit...

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Literature Corpus work: f83c0f64-e53d-5454-bf60-7e9a14274a82
DOI: 10.1101/2025.11.04.685750

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