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Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates <i>Toxoplasma</i> dissemination

2024-02-07

Abstract excerpt

Mononuclear phagocytes facilitate the dissemination of the obligate intracellular parasite Toxoplasma gondii . Here, we report how a set of secreted parasite effector proteins from dense granule organelles (GRA) orchestrates dendritic cell-like chemotactic and pro-inflammatory activation of parasitized macrophages. These effects enabled efficient dissemination of the type II T. gondii lineage, a highly prevalent...

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Identifiers and source

Literature Corpus work
98a785a0-0512-5804-8fbe-88da48219fe2
DOI
10.1101/2024.02.06.579146
Open publication

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Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates <i>Toxoplasma</i> disseminationDOI 10.1101/2024.02.06.579146
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