Article

Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus Chip

2021-04-27

Abstract excerpt

<h4>ABSTRACT</h4> Mechanical forces associated with breathing play a fundamental role in lung development and disease but the molecular pathways remain largely unknown. Here, we used a mechanically actuatable Human Lung Alveolus Chip that recapitulates human lung alveolar type I and type II cell differentiation, alveolar-capillary interface formation, and genome-wide gene expression profiles characteristic of the...

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Literature Corpus work: 8bc342e2-70c6-5281-a33c-30a80ce21179
DOI: 10.1101/2021.04.26.441498

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