Article

Mechanical Ventilation Stimulates Expression of ACE2, the Receptor for SARS-Cov-2

2020-05-26

Abstract excerpt

The SARS-Cov-2 virus, which causes COVID 19, uses the cell surface protein ACE2 as receptor for entry into cells. Critically ill COVID-19 patients often require prolonged mechanical ventilation which can cause mechanical stress to lung tissue. In vitro studies have shown that expression of ACE2 in alveolar cells is increased following mechanical stretch and inflammation. Therefore, we analyzed transcriptome datase...

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Literature Corpus work: c06ec12e-61c4-5993-af62-77e80db71e91
DOI: 10.20944/preprints202005.0429.v1

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