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Exploring the host response in infected lung organoids using NanoString technology: A statistical analysis of gene expression data

26 Nov 2024

Abstract excerpt

In this study, we used a three-dimensional airway "organ tissue equivalent" (OTE) model at an air-liquid interface (ALI) to mimic human airways. We investigated the effects of three viruses (Influenza A virus (IAV), Human metapneumovirus (MPV), and Parainfluenza virus type 3 (PIV3) on this model, incorporating various control conditions for data integrity. Our primary objective was to assess gene expression using...

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PMID: 39591472
DOI: 10.1371/journal.pone.0308849

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