Article

Autologous human iPSC-derived Alveolus-on-Chip reveals early pathological events of <i>M. tuberculosis</i> infection

2025-03-17

Abstract excerpt

Immunocompetent and experimentally accessible alveolar systems to study human respiratory diseases are lacking. Here, we developed a single donor human induced pluripotent stem cell (iPSC)-derived Lung-on-Chip (iLoC) containing Type II and I alveolar epithelial cells, vascular endothelial cells, and macrophages in a microfluidic device that mimic lung 3D mechanical stretching and air-liquid interface. Imaging and...

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Literature Corpus work: 6daf1986-80a0-529c-acd1-7027224af66a
DOI: 10.1101/2025.03.14.643230

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Autologous human iPSC-derived Alveolus-on-Chip reveals early pathological events of <i>M. tuberculosis</i> infectionDOI 10.1101/2025.03.14.643230Read

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