Article

Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses

2025-04-01

Abstract excerpt

In this study, we developed novel lung organoid-on-chip models that elucidate differential human tissue response to various strains of respiratory pathogens: Streptococcus pneumoniae and SARS-CoV-2. We show that human fetal-derived distal lung epithelial cells are readily expandable in 3D as organoids, thereby providing a highly sustainable source of lung progenitor cells. These 3D organoid progenitors can then b...

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Literature Corpus work: a341ca57-28e1-5b0d-bbce-badc35adcae0
DOI: 10.1101/2025.03.31.644992

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