Article

Host serine proteases and antiviral innate immunity as potential therapeutic targets in influenza A virus infection-induced COPD exacerbations

2025-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Lung manifestations of chronic obstructive pulmonary disease (COPD) are often exacerbated by influenza A virus infections; however, the underlying mechanisms remain largely unknown and hence, therapeutic options are limited. Using a physiologically relevant human lung airway-on-a-chip (Airway Chip) microfluidic culture model lined with human airway epithelium from COPD or healthy donors interfac...

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Literature Corpus work: 59a7e344-942f-5e20-a048-24ee506b6547
DOI: 10.1101/2025.02.02.25321231

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