Article

Transcriptional regulation by NR5A2 couples cell differentiation and inflammation in the pancreas

2017-10-26

Abstract excerpt

Tissue-specific differentiation and inflammatory programmes are thought to independently contribute to disease. The orphan nuclear receptor NR5A2 is a key regulator of pancreas differentiation and SNPs in or near the human gene are associated with risk of pancreatic cancer. In mice, Nr5a2 heterozygosity sensitizes the pancreas to damage, impairs regeneration, and cooperates with mutant KRas in tumor progression....

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Literature Corpus work: 8bb54f6a-f687-5901-a1ab-8bcb6b52c572
DOI: 10.1101/209411

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