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Article

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

Development (Cambridge, England) - 1 Aug 2014

Hale Michael A, Swift Galvin H, Hoang Chinh Q, Deering Tye G, Masui Toshi, Lee Youn-Kyoung, Xue Jumin, MacDonald Raymond J

Abstract excerpt

The orphan nuclear receptor NR5A2 is necessary for the stem-like properties of the epiblast of the pre-gastrulation embryo and for cellular and physiological homeostasis of endoderm-derived organs postnatally. Using conditional gene inactivation, we show that Nr5a2 also plays crucial regulatory roles during organogenesis. During the formation of the pancreas, Nr5a2 is necessary for the expansion of the nascent...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25063451
DOI: 10.1242/dev.109405
PMCID: PMC4197540

Genes

BHLHA15
FOXA2
GATA4
MYC
RBPJL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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