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Article

More than acinar identity? A novel cystic phenotype suggests broader roles for NR5A2 in pancreatic cancer†.

The Journal of pathology - 1 May 2021

Aney Katherine J, Nissim Sahar

Abstract excerpt

The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains dismal. Multiple genome-wide association studies (GWAS) have implicated the nuclear receptor NR5A2 in modulating PDAC risk, but mechanisms for this association are not understood. NR5A2 is a transcription factor that maintains acinar cell identity, and heterozygous loss of Nr5a2 in mice accelerates oncogenic Kras-driven formation of pancreatic...

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Share to Acinar Cells
Share to Carcinoma, Pancreatic Ductal
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Cytoplasmic and Nuclear

Source

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Identifiers

PMID: 33448017
DOI: 10.1002/path.5619
PMCID: PMC8439571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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