A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA.

doi:10.1038/s41467-024-54151-y

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Article

A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA.

Nature communications - 12 Nov 2024

Li Yinglei, Zheng Ran, Jiang Lai, Yan Chenchao, Liu Ran, Chen Luyi, Jin Wenwen, Luo Yuanyuan, Zhang Xiafei, Tang Jun, Dai Zhe, Jiang Wei

Abstract excerpt

Human genetics analysis has identified many noncoding SNPs associated with diabetic traits, but whether and how these variants contribute to diabetes is largely unknown. Here, we focus on a noncoding variant, rs6048205, and report that the risk-G variant impairs the generation of PDX1+/NKX6-1+ pancreatic progenitor cells and further results in the abnormal decrease of functional β cells during pancreatic...

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Identifiers

PMID: 39532884
DOI: 10.1038/s41467-024-54151-y
PMCID: PMC11557932

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