Article

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and suppresses PDAC initiation

2021-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Tissue-specific differentiation is driven by specialized transcriptional networks. Pancreatic acinar cells crucially rely on the PTF1 complex, and on additional transcription factors, to deploy their transcriptional program. Here, we identify NFIC as a novel regulator of acinar differentiation using a variety of methodological strategies. NFIC binding sites are found at very short distances from...

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Literature Corpus work: 1d1744c3-0ed6-5708-979e-735ccb8acde4
DOI: 10.1101/2021.08.09.455477

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