Article

Exploring the association between Body Mass Index, Sex and Gene Expression in human colorectal epithelium

2022-11-24

Abstract excerpt

<h4>Introduction</h4> Colorectal cancer (CRC) is the second most common cause of cancer death globally. Genome-wide association studies have established that cancer risk mediated through common genetic variants can be linked to variation in gene expression. Since obesity and male sex impart substantially elevated CRC risk, we studied transcriptional profiles of normal colorectal mucosa using RNA sequencing to bet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d9d50ce-a54c-5799-a188-4e6912b73d09
DOI: 10.1101/2022.11.21.515057

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring the association between Body Mass Index, Sex and Gene Expression in human colorectal epitheliumDOI 10.1101/2022.11.21.515057Read

Sex Differences in Colorectal Cancer: Epidemiology, Risk Factors, and Clinical OutcomesSemantic proximity Read

Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes.Semantic proximity Read

Integrating multi-tissue expression and splicing data to prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes with therapeutic potentialSemantic proximity Read

Association Analysis between Body Mass Index and Genomic DNA Methylation across 15 Major Cancer TypesSemantic proximity Read

Factors influencing patterns of gene expression in large bowel mucosaSemantic proximity Read

Association between differential gene expression and body mass index among endometrial cancers from The Cancer Genome Atlas ProjectSemantic proximity Read

The Importance of Sex in the Discovery of Colorectal Cancer Prognostic BiomarkersSemantic proximity Read

Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal CancersSemantic proximity Read

The tumor multi-omic landscape of endometrial cancers developed on a germline genetic background of adipositySemantic proximity Read

Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants.Semantic proximity Read

Sex Steroid Receptors in Colorectal Cancer: Implications for Tumor Progression, Therapeutic Opportunities, and Sex-Specific OutcomesSemantic proximity Read

Body fatness associations with cancer: evidence from recent epidemiological studies and future directionsSemantic proximity Read